US has indicted all their close people, and has taken one after another in Mexico, to be extradited. Chubas was one that got away, but there are at least 3 more, plus Mini Lic telling everything he knows to DEA in San Diego, it's a matter of time.
Idk.. maybe I'm wrong but I don't think their time is quite up yet. If they stay close with Zambada and follow his lead, they might last a while. Guano is still out and about, and another of Chapo's brothers just got out. They just need to stay in the woods/mountains and throw away any cell phones..